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Human poo pumped through a patient's nose used as superbug medicine

THURSDAY, MAY 8, 2014 7:03 AM GMT

Treatment known as faecal transplant restores bacterial balance in the stomach and kills the superbug

Australian Associated Press

Doctors are using human poo pumped through a patient's nose as a medicine for a super stomach bug.

The medicine is liquefied, but not treated in any way, and reaches the patient's stomach via a tube. It restores bacterial balance and kills the bug, says associate professor Ian Seppelt, an Australian intensive care doctor and anaesthetist.

So far the treatment, known as faecal transplant, has been tested only on a drug resistant form of the bowel disease caused by the bacterium clostridium difficile. Antibiotics are unreliable against the superbug, but the transplant is 95% successful, saving patients from constant stomach cramps and chronic diarrhoea.

"It sounds radical but it makes a lot of sense," said Seppelt on Thursday at a gathering of more than 4,000 Australasian anaesthetists and surgeons. "Usually patients are sufficiently miserable to go ahead, often using a donation from a relative."

Healthy humans have about 100 times more bacteria cells in their gut than their own cells.

"These good bacteria are essential to keep us alive."

But serious problems start if a large number are killed by antibiotics, leaving an opening for dangerous bacteria to take their place, as happens with the superbug. Seppelt is part of a team comparing the gut bacteria of intensive care patients across Australia.

"Our major concern is the development of resistant organisms in patients who are critically ill.

"We are trying to get the balance right, but we are pretty much ignorant of what we are doing to the normal bacteria in the gut," said Seppelt, from the University of Sydney.

The aim is to assess the consequences of putting lots of sick people close together with the potential for bacteria to spread from one to the other. They also want to see if the gut bacteria differs from one hospital to another.

"We want to get a snapshot of many intensive care units around Australia and see if what is happening in these patients is the same or if it differs from one hospital to another.

"We are also interested in finding out how bacteria in the bowel changes from day to day with the administration of antibiotics."

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